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In our analyze, we were capable to appreciably escalate the dose of CX-5461 over and above that accomplished in the initial-in-human review in sufferers with hematologic cancers. The RP2D of 475 mg/m2 on days 1, 8, and fifteen of a 4-7 days cycle, was based upon phototoxicity, which transpired Inspite of stringent UV light avoidance protocols and